TETRAHYDROISOQUINOLINE DERIVATIVE

To provide a pharmaceutical composition for treating a disease or condition which responds to modulation of contractility of skeletal muscle sarcomere.SOLUTION: Provided is a tetrahydroisoquinoline derivative compound such as a compound exemplified by (-)-2-(difluoromethyl)-8-ethyl-8-(2-hydroxyethyl...

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Main Authors SATO IPPEI, MATSUSHIMA YUJI, TANAKA HIROAKI, LUKE ASHCRAFT, MIURA MICHINORI, KAMIKUBO TAKASHI, KIYOHARA HIROSHI, SCOTT EMILE COLLIBEE, YAMAKI SHIN, MARC GARARD, SAITO TOMOYUKI, FADY MALIK, SHIINA YASUHIRO, JEFFREY MICHAEL WARRINGTON, OE SOSUKE, BRADLEY PAUL MORGAN, MIHARA KAYOKO, LU PU-PING
Format Patent
LanguageEnglish
Japanese
Published 13.05.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a pharmaceutical composition for treating a disease or condition which responds to modulation of contractility of skeletal muscle sarcomere.SOLUTION: Provided is a tetrahydroisoquinoline derivative compound such as a compound exemplified by (-)-2-(difluoromethyl)-8-ethyl-8-(2-hydroxyethyl)-6H-spiro[1,6-naphthyridine-5,3'-oxetane]-7(8H)-on, and the like.SELECTED DRAWING: Figure 1 【課題】骨格筋サルコメアの収縮性の調節に応答する疾患または状態を治療するための医薬組成物を提供する。【解決手段】（−）−２−（ジフルオロメチル）−８−エチル−８−（２−ヒドロキシエチル）−６Ｈ−スピロ［１，６−ナフチリジン−５，３'−オキセタン］−７（８Ｈ）−オンで例示される化合物等の、テトラヒドロイソキノリン誘導体化合物による。【選択図】図１
Bibliography:Application Number: JP20210014223