CRYSTALLINE COMPOUND AS SEMICARBAZIDE-SENSITIVE AMINE OXIDASE ENZYME INHIBITOR

• Main Author: EDWARD SAVORY
• Format: Patent
• Language: English; Japanese
• Published: 13.05.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a crystalline form of the mesylate salt of (3S)-tetrahydrofuran-3-yl(4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate having high thermal stability, ease of filtration, ease of drying, and reduced hygroscopicity.SOLUTION: There are provided: a specific crystalline mesylate salt of (3S)-tetrahydrofuran-3-yl(4S)-4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate, and the use of the same in medicine. (Formula (I)).SELECTED DRAWING: None 【課題】高い熱的安定性、ろ過の容易性、乾燥の容易性、および吸湿性が低減した（３Ｓ）−テトラヒドロフラン−３−イル（４Ｓ）−４−イソプロピル−１，４，６，７−テトラヒドロ−５Ｈ−イミダゾ［４，５−ｃ］ピリジン−５−カルボキシレートのメシレート塩の結晶形態の提供。【解決手段】本発明は、（３Ｓ）−テトラヒドロフラン−３−イル （４Ｓ）−４−イソプロピル−１，４，６，７−テトラヒドロ−５Ｈ−イミダゾ［４，５−ｃ］ピリジン−５−カルボキシレートの特定の結晶性メシレート塩および医薬におけるその使用を提供する。（式（Ｉ））【選択図】 なし