BINDING MOLECULES

To provide binding molecules that can immunospecifically bind to an epitope of 5T4.SOLUTION: There is provided tri-specific binding molecules, which are multichain polypeptide molecules capable of mediating coordinated binding to three epitopes, and which includes CDRL1 having the sequence RASQGISNY...

Full description

Saved in:
Bibliographic Details
Main Authors BHASWATI BARAT, JOHNSON LESLIE S, LING HUANG, KALPANA SHAH, STEPHEN JAMES BURKE, GURUNADH REDDY CHICHILI, PAUL A MOORE, LIU LIQIN, CHIA-YING KAO LAM, EZIO BONVINI
Format Patent
LanguageEnglish
Japanese
Published 13.05.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:To provide binding molecules that can immunospecifically bind to an epitope of 5T4.SOLUTION: There is provided tri-specific binding molecules, which are multichain polypeptide molecules capable of mediating coordinated binding to three epitopes, and which includes CDRL1 having the sequence RASQGISNYLA, CDRL2 having the sequence RANRLQS, and CDRL3 having the sequence LQYDDFPWT.SELECTED DRAWING: Figure 4A 【課題】５Ｔ４のエピトープに免疫特異的に結合できる結合分子を提供する。【解決手段】３つのエピトープへの配位結合を仲介できる多重鎖ポリペプチド分子である、三重特異性結合分子であって、配列ＲＡＳＱＧＩＳＮＹＬＡを有するＣＤＲＬ１と、配列ＲＡＮＲＬＱＳを有するＣＤＲＬ２と、及び配列ＬＱＹＤＤＦＰＷＴを有するＣＤＲＬ３とを含む。【選択図】図４Ａ
Bibliography:Application Number: JP20210006240