ANTI CD3 ANTIBODY, ANTI CD123 ANTIBODY AND BISPECIFIC ANTIBODY WHICH BINDS SPECIFICALLY TO CD3 AND/OR CD123

• Main Authors: JANA ALBRECHT, MARIE-CECILE WETZEL, CHRISTIAN LANGE, PETER WONEROW, CHIRSTIAN BIEL, MARION SCHNEIDER, ERCOLE RAO, KATJA KROLL, JOCHEN BENINGA, CENDRINE LEMOINE, STEPHANE GUERIF, CHANTAL CARREZ, CEDRIC BARRIERE, WULF-DIRK LEUSCHNER
• Format: Patent
• Language: English; Japanese
• Published: 13.05.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

To provide an anti CD3 antibody, an anti CD123 antibody, and a bispecific antibody which binds specifically, to CD3 and/or CD123.SOLUTION: There is provided an antibody-like binding protein which specifically binds to CD3, and specifically binds to at least one further antibody, for example, CD123. There is provided an antibody like binding protein which specifically binds to CD123, and specifically binds to at least one further antibody. There are also provided, an anti CD3 antibody and an anti CD123 antibody. There are also provided, a pharmaceutical composition including an antibody like binding protein, an anti CD3 antibody or anti CD123 antibody, and use thereof for treating cancer. There is also provided use of the antibody-like binding protein as a diagnostic tool of an isolated nucleic acid including a sequence for encoding the antibody like binding protein, the anti CD3 or anti CD123 antibody, a vector, a host cell, and anti CD 123 antibody.SELECTED DRAWING: None 【課題】抗ＣＤ３抗体、抗ＣＤ１２３抗体及びＣＤ３及び／又はＣＤ１２３に特異的に結合する二重特異性抗体を提供する。【解決手段】ＣＤ３に特異的に結合し、かつ少なくとも１つのさらなる抗原、例えばＣＤ１２３に特異的に結合する抗体様結合タンパク質に関する。ＣＤ１２３に特異的に結合し、かつ少なくとも１つのさらなる抗原に特異的に結合する抗体様結合タンパク質に関する。さらに、抗ＣＤ３抗体及び抗ＣＤ１２３抗体に関する。また、抗体様結合タンパク質、抗ＣＤ３抗体又は抗ＣＤ１２３抗体を含む医薬組成物、及び癌を処置するためのそれらの使用に関する。さらに、上記抗体様結合タンパク質、抗ＣＤ３又は抗ＣＤ１２３抗体をコードする配列を含む単離された核酸、ベクター及び宿主細胞、並びに上記抗ＣＤ１２３抗体の診断ツールとしての使用に関する。【選択図】なし