MARKER SYSTEM, ESPECIALLY MARKER SYSTEM FOR BACULOVIRUS-EXPRESSED SUBUNIT ANTIGENS

• Main Authors: ARUN V IYER, JOSEPH RALPH HERMANN, ERIC MARTIN VAUGHN, MERRILL LYNN SCHAEFFER, ROOF MICHAEL B
• Format: Patent
• Language: English; Japanese
• Published: 13.05.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

To provide compliance markers and marker vaccines allow for the differentiation between infected and vaccinated individuals, and a method for determining whether or not an individual has received an immunogenic composition including a recombinant protein produced in cultured insect cells by a baculovirus expression system.SOLUTION: A method of the invention comprises a step for determining presence/absence of one or more markers in a biological sample obtained from an individual, the marker indicates a fact that, one or more antigens derived from a virus being a RNA virus which can infect an insect cell, have been received by the individual, and presence of the one or more markers in the biological sample indicates a fact that the individual has received an immunogenic composition.SELECTED DRAWING: None 【課題】感染個体とワクチン接種個体との識別を可能にするコンプライアンスマーカー及びマーカーワクチン、バキュロウイルス発現系によって培養昆虫細胞で生成された組換えタンパク質を含む免疫原性組成物を個体が受容したか否かを決定する方法を提供する。【解決手段】個体から入手された生物学的サンプルにおいて1つ以上のマーカーの有無を決定する工程を含み、前記マーカーは、昆虫細胞に感染できるRNAウイルスであるウイルスに由来する1つ以上の抗原を当該個体が受容したことを示し、前記生物学的サンプル中の前記1つ以上のマーカーの存在は前記個体が前記免疫原性組成物を受容したことを示す、方法。【選択図】なし