EPIGENETIC MARKERS OF COLORECTAL CANCER AND DIAGNOSTIC METHODS USING THOSE MARKERS

• Main Authors: HORACE DREW, KONSTA RAINER DUESING, PETER LAURENCE MOLLOY, MICHAEL BUCKLEY, XU ZHENG-ZHOU, JASON PETER ROSS, SUSAN MARGARET MITCHELL
• Format: Patent
• Language: English; Japanese
• Published: 22.04.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

To provide epigenetic markers of colorectal cancer and diagnostic methods using the markers.SOLUTION: A method of screening for the onset or predisposition to the onset of a large intestine neoplasm in an individual comprises assessing the methylation status of a DNA region selected from gene regions including 2-kb upstream of the transcription start site of one or more of specific gene groups in a biological sample from the individual, where a higher level of methylation of the DNA regions than control levels is indicative of a large intestine neoplasm or a predisposition to the onset of a large intestine neoplastic state.SELECTED DRAWING: None 【課題】結腸直腸がんのエピジェネティックマーカー及び該マーカーを使用する診断法を提供する。【解決手段】個体における大腸新生物の発症若しくは発症の素因についてスクリーニングする方法であって、個体由来の生体試料において、特定の遺伝子群の１つ又は複数の転写開始部位の２ｋｂ上流を含む遺伝子領域から選択されるＤＮＡ領域のメチル化状態を評価することを含み、対照レベルと比べてＤＮＡ領域のメチル化のより高いレベルは大腸新生物又は大腸新生物状態の発症の素因を示す、方法である。【選択図】なし