DEGRADABLE MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVE

• Main Authors: YOSHIOKA HIROKI, NISHIYAMA NOBUHIRO, OSAKAMA KAZUKI, HAMURA TAKESHI
• Format: Patent
• Language: English; Japanese
• Published: 08.04.2021
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP

To provide a high-molecular-weight degradable multi-arm polyethylene glycol derivative that does not cause cell vacuoles.SOLUTION: A degradable polyethylene glycol derivative is represented by the following formula (1): (In the formula, n1 and n2 are each independently 45-950; W1 and W2 are each independently an oligopeptide having 2-47 residues; a1 and a2 are each independently 1-8; Q is a C2-C12 hydrocarbon chain which may contain an oxygen atom and/or a nitrogen atom; X1 and X2 are each independently a functional group capable of reacting with a biological substance; and L1, L2, L3, L4, L5, and L6 are each independently a divalent spacer).SELECTED DRAWING: None 【課題】細胞の空胞を引き起こさない高分子量のマルチアーム型の分解性ポリエチレングリコール誘導体を提供すること。【解決手段】下式（１）：（式中、ｎ１及びｎ２はそれぞれ独立して４５〜９５０であり、Ｗ１及びＷ２はそれぞれ独立して２〜４７残基のオリゴペプチドであり、a１及びa２はそれぞれ独立して１〜８であり、Ｑは２〜１２の炭素原子を有した酸素原子及び／又は窒素原子を含んでも良い炭化水素鎖であり、Ｘ１及びＸ２はそれぞれ独立して生体関連物質と反応可能な官能基であり、Ｌ１及びＬ２及びＬ３及びＬ４及びＬ５及びＬ６はそれぞれ独立して、２価のスペーサーである。）で示される分解性ポリエチレングリコール誘導体。【選択図】なし