TREATMENT METHOD COMBINING MDM2 INHIBITOR AND BTK INHIBITOR
To provide a drug/cancer treatment method that combines a compound exhibiting MDM2 inhibitory activity and a compound exhibiting BTK inhibitory activity.SOLUTION: Provided is a drug or combined treatment method is obtained by combining: (3'R,4'S,5'R)-N-[(3R,6S)-6-carbamoyltetrahydro-2...
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Format | Patent |
Language | English Japanese |
Published |
08.04.2021
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Subjects | |
Online Access | Get full text |
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Summary: | To provide a drug/cancer treatment method that combines a compound exhibiting MDM2 inhibitory activity and a compound exhibiting BTK inhibitory activity.SOLUTION: Provided is a drug or combined treatment method is obtained by combining: (3'R,4'S,5'R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6"-chloro-4'-(2-chloro-3-fluoropyridine-4-yl)-4,4-dimethyl-2"-oxo-1",2"-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3"-indole]-5'-carboxamide, or a pharmaceutically acceptable salt thereof; and ibrutininb or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: None
【課題】MDM2阻害活性を有する化合物とBTK阻害活性を有する化合物とを組み合わせてなる医薬/がんの治療方法を提供すること。【解決手段】(3'R,4'S,5'R)−N−[(3R,6S)−6−カルバモイルテトラヒドロ−2H−ピラン−3−イル]−6"−クロロ−4'−(2−クロロ−3−フルオロピリジン−4−イル)−4,4−ジメチル−2"−オキソ−1",2"−ジヒドロジスピロ[シクロヘキサン−1,2'−ピロリジン−3',3"−インドール]−5'−カルボキサミドもしくはその薬学的に許容される塩とイブルチニブもしくはその薬学的に許容される塩とを組み合わせてなる医薬または併用治療方法を提供する。【選択図】なし |
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Bibliography: | Application Number: JP20210002016 |