METHOD OF SYNTHESIS OF (1R, 2R, 5R)-5-AMINO-2-METHYLCYCLOHEXANOL HYDROCHLORIDE AND INTERMEDIATE USEFUL THEREIN

To provide methods for making (1R, 2R, 5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.SOLUTION: (1R, 2R, 5R)-5-amino-2-methylcyclohexanol is obtained by us...

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Main Authors HON-WAH MAN, PERIYANDI NAGARAJAN, CHINNAPILLAI RAJENDIRAN, TERRENCE JOSEPH CONNOLLY, JASTI VENKATESWARLU
Format Patent
LanguageEnglish
Japanese
Published 25.03.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:To provide methods for making (1R, 2R, 5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.SOLUTION: (1R, 2R, 5R)-5-amino-2-methylcyclohexanol is obtained by using a compound of a formula (1) and a compound of a formula (2) as starting materials and through predetermined 8 steps.SELECTED DRAWING: Figure 1 【課題】ＪＮＫ経路に関連する疾患、障害、または病態の治療に有用な化合物の調製に有用である、（１Ｒ，２Ｒ，５Ｒ）−５−アミノ−２−メチルシクロヘキサノール塩酸塩を調製する方法を提供する。【解決手段】式（１）の化合物、及び、式（２）の化合物を出発原料として、特定の８ステップを経て、（１Ｒ，２Ｒ，５Ｒ）−５−アミノ−２−メチルシクロヘキサノールを得る。【選択図】図１
Bibliography:Application Number: JP20200200723