PROCESS FOR PREPARING BTK INHIBITORS

• Main Authors: TIAN QINGPING, ALEXANDER GMEHLING, SUSHANT MALHOTRA, DANIAL BEAUDRY, THERESA CRAVILLION, ZHANG HAIMING, LIM NGIAP-KIE, ALEC FETTES, FRANCIS GOSSELIN, STEFAN BACHMANN
• Format: Patent
• Language: English; Japanese
• Published: 18.03.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide methods for preparing the Bruton's Tyrosine Kinase ("BTK") inhibitor compound.SOLUTION: Methods for preparing 2-{3'-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4']bipyridinyl-2'-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.SELECTED DRAWING: None 【課題】ブルトンチロシンキナーゼ（「BTK」）阻害剤化合物を調製する方法の提供。【解決手段】２−｛３'−ヒドロキシメチル−１−メチル−５−［５−（（Ｓ）−２−メチル−４−オキセタン−３−イル−ピペラジン−１−イル）−ピリジン−２−イルアミノ］−６−オキソ−１，６−ジヒドロ−［３，４'］ビピリジニル−２'−イル｝−７，７−ジメチル−３，４，７，８−テトラヒドロ−２Ｈ，６Ｈ−シクロペンタ［４，５］ピロロ［１，２−ａ］ピラジン−１−オンを調製する方法。【選択図】なし