PARTICLE, PARTICLE FOR COAGULATION METHOD, REAGENT INCLUDING THE SAME, KIT, AND DETECTION METHOD

• Main Authors: NATORI MAKOTO, NAKAHAMA KAZUMICHI, YAMAUCHI FUMIO, SUDA SAKAE, KANEZAKI KENGO, TSUBAKI KEIICHIRO, SUZUKI MASARO
• Format: Patent
• Language: English; Japanese
• Published: 01.03.2021
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

To provide a particle the nonspecific adsorption of which is small and which has a reactive functional group for chemically bonding a ligand and is suitable for a coagulation method, a particle for the coagulation method which is composed of chemically bonded ligand, a reagent for extracorporeal diagnosis that includes the same, a kit, and a target substance detection method.SOLUTION: Provided is a particle containing a polymer which includes a unit having a linker A in a side chain. When both ends of the linker A are expressed by X1, X2, the linker A has a reactive functional group for chemically bonding a ligand at one of X1 and X2, and one of the X1 and X2 of the linker A includes an ester structure. The particle is characterized in that the sum of bonds between atoms linearly linking from the X1 to the X2 of the linker A is in the range of 18 to 24 inclusive, and the X1 and X2 include CH2 or CH.SELECTED DRAWING: None 【課題】非特異吸着が小さく、且つ、リガンドを化学結合するための反応性官能基を有し、凝集法に好適な粒子、リガンドが化学結合してなる凝集法用粒子、及び、これを含む体外診断用試薬、キット、並びに標的物質の検出方法を提供する。【解決手段】側鎖にリンカーＡを有するユニットを有するポリマーを含む粒子であって、リンカーＡの両末端をＸ１、Ｘ２で表記した場合、リンカーＡが、Ｘ１、または、Ｘ２の一方に、リガンドを化学結合するための反応性官能基を有し、且つ、リンカーＡのＸ１、または、Ｘ２の一方がエステル構造を含み、リンカーＡのＸ１からＸ２を直鎖状に結ぶ原子間のボンドの和が１８以上２４以下の範囲であり、Ｘ１及びＸ２がＣＨ２、またはＣＨを含むことを特徴とする粒子。【選択図】なし