CATALYST-FREE SURFACE FUNCTIONALIZATION AND POLYMER GRAFTING

• Main Authors: WAYNE N GEORGE, ANDREW A BROWN, LORENZO BERTI
• Format: Patent
• Language: English; Japanese
• Published: 04.02.2021
• Subjects: CHEMICAL COMPOSITION OF GLASSES, GLAZES, OR VITREOUSENAMELS; CHEMISTRY; GLASS; JOINING GLASS TO GLASS OR OTHER MATERIALS; LAYERED PRODUCTS; LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT ORNON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM; METALLURGY; MINERAL OR SLAG WOOL; ORGANIC CHEMISTRY; PEPTIDES; PERFORMING OPERATIONS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS,MINERALS OR SLAGS; SURFACE TREATMENT OF GLASS; TRANSPORTING

To provide a substrate that considers cost of materials, compatibility with manufacturing processes, and stability during storage and shipping, and supports downstream chemical processing steps such as nucleic acid amplification and sequencing.SOLUTION: A substrate has a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. The silane or silane derivative contains optionally substituted norbornene or norbornene derivatives.SELECTED DRAWING: None 【課題】材料の費用、工業法との適合性、保管および輸送の間の安定性、ならびに核酸増幅および配列決定などの下流の化学的な処理工程を支援する基材を提供する。【解決手段】ポリマー、ヒドロゲル、アミノ酸、ヌクレオシド、ヌクレオチド、ペプチド、ポリヌクレオチド，またはタンパク質などの目的の官能基化分子を用いて直接コンジュゲートするための、必要に応じて置換されているシクロアルケンまたは必要に応じて置換されているヘテロシクロアルケンに共有結合しているシランまたはシラン誘導体を含む表面を有する基材であって、シランまたはシラン誘導体は、必要に応じて置換されているノルボルネンまたはノルボルネン誘導体を含有する。【選択図】なし