COMBINATION THERAPY METHOD USING MDM2 INHIBITOR AND DNA METHYLTRANSFERASE INHIBITOR

• Main Author: SEKI TAKEHIKO
• Format: Patent
• Language: English; Japanese
• Published: 21.01.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a medicament and a method for treating cancer, comprising a compound having MDM2 inhibiting activity and a DNA methyltransferase inhibitor in combination.SOLUTION: The present invention provides a medicament or a combination therapy comprising (3'R,4'S,5'R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6"-chloro-4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2"-oxo-1",2"-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3"-indole]-5'-carboxamide or a pharmaceutically acceptable salt thereof and a DNA methyltransferase inhibitor in combination.SELECTED DRAWING: None 【課題】MDM2阻害活性を有する化合物とDNAメチルトランスフェラーゼ阻害剤とを組み合わせてなる医薬／がんの治療方法の提供。【解決手段】（３'Ｒ，４'Ｓ，５'Ｒ）−Ｎ−［（３Ｒ，６Ｓ）−６−カルバモイルテトラヒドロ−２Ｈ−ピラン−３−イル］−６"−クロロ−４'−（２−クロロ−３−フルオロピリジン−４−イル）−４，４−ジメチル−２"−オキソ−１"，２"−ジヒドロジスピロ［シクロヘキサン−１，２'−ピロリジン−３'，３"−インドール］−５'−カルボキサミドまたはその薬学的に許容される塩とDNAメチルトランスフェラーゼ阻害剤とを組み合わせて医薬または併用治療法の提供。【選択図】なし