COMPOSITIONS AND METHODS OF INHIBITING MASP-1 AND/OR MASP-2 AND/OR MASP-3 FOR TREATMENT OF VARIOUS DISEASES AND DISORDERS

To provide methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from, or at risk for developing, a disease or disorder by administering to the subject a composition comprising a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3-dependen...

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Bibliographic Details
Main Authors THOMAS DUDLER, PATRICK GRAY, GREGORY A DEMOPULOS, HANS-WILHELM SCHWAEBLE
Format Patent
LanguageEnglish
Japanese
Published 21.01.2021
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from, or at risk for developing, a disease or disorder by administering to the subject a composition comprising a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3-dependent complement activation.SOLUTION: A MASP-2 inhibitory agent and a MASP-1 inhibitory agent are administered; a MASP-2 inhibitory agent and a MASP-3 inhibitory agent are administered; a MASP-3 inhibitory agent and a MASP-1 inhibitory agent are administered; or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent are administered.SELECTED DRAWING: Figure 1 【課題】MASP-3依存性補体活性化を阻害するのに有効な量のMASP-3阻害物質を含む組成物を、疾患もしくは障害に罹患している該対象または該疾患もしくは該障害を発症する危険のある対象に投与する工程により、該対象においてMASP-3依存性補体活性化を阻害するための方法および組成物の提供。【解決手段】MASP-2阻害物質およびMASP-1阻害物質を投与されるか、MASP-2阻害物質およびMASP-3阻害物質を投与されるか、MASP-3阻害物質およびMASP-1阻害物質を投与されるか、または、MASP-1阻害物質、MASP-2阻害物質、およびMASP-3阻害物質を投与される。【選択図】図１
Bibliography:Application Number: JP20200163180