FACTOR VIII ZWITTERIONIC POLYMER CONJUGATES

To provide Factor VIII with an increased in vivo half-life while retaining sufficient biological activity.SOLUTION: A conjugate comprises recombinant FVIII and a zwitterionic polymer, where the polymer comprises one or more monomer units and where at least one monomer unit comprises a zwitterionic g...

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Bibliographic Details
Main Authors MARTIN LINSELL, WAYNE TO, D VICTOR PERLROTH, SONG LI, JAMES AGGEN, DIDIER BENOIT, STEPHEN A CHARLES
Format Patent
LanguageEnglish
Japanese
Published 12.11.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:To provide Factor VIII with an increased in vivo half-life while retaining sufficient biological activity.SOLUTION: A conjugate comprises recombinant FVIII and a zwitterionic polymer, where the polymer comprises one or more monomer units and where at least one monomer unit comprises a zwitterionic group. Optionally, the zwitterionic group comprises phosphorylcholine, and the monomer comprises 2-(acryloyloxyethyl)-2'-(trimethylammoniumethyl) phosphate.SELECTED DRAWING: Figure 2 【課題】十分な生物活性を保持しながら、インビボ半減期が増加した第ＶＩＩＩ因子を提供する。【解決手段】組換えＦＶＩＩＩと両性イオンポリマーとを含むコンジュゲートであって、ポリマーは１つまたは複数のモノマー単位を含み、少なくとも１つのモノマー単位は両性イオン基を含むコンジュゲートを開示する。場合により、両性イオン基がホスホリルコリン、モノマーが２−（アクリロイルオキシエチル）−２'−（トリメチルアンモニウムエチル）ホスフェートを含む。【選択図】図２
Bibliography:Application Number: JP20200117047