HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS BTK ACTIVITY INHIBITOR

• Main Authors: WENDY B YOUNG, WEI BINQING, JAMES JOHN CRAWFORD, DANIEL FRED ORTWINE
• Format: Patent
• Language: English; Japanese
• Published: 12.11.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide compounds useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase.SOLUTION: The invention provides compounds represented by the general formula in the figure, specifically, 2-(4-(hydroxymethyl)-5-(1-methyl-5-(5-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)pyridin-3-yl)-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-1(2H)-one, and the like.SELECTED DRAWING: None 【課題】Ｂｔｋキナーゼを阻害し、Ｂｔｋキナーゼによって媒介される炎症などの免疫障害を治療する上で有用な化合物の提供。【解決手段】下記一般式で表され、具体的には、２−（４−（ヒドロキシメチル）−５−（１−メチル−５−（５−（４−（オキセタン−３−イル）ピペラジン−１−イル）ピリジン−２−イルアミノ）−６−オキソ−１，６−ジヒドロピリジン−３−イル）ピリジン−３−イル）−３，４，６，７，８，９−ヘキサヒドロピラジノ［１，２−ａ］インドール−１（２Ｈ）−オン等の化合物。【選択図】なし