ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE

• Main Authors: BANUELOS CARMEN ADRIANA, RAYMOND J ANDERSEN, MARIANNE DOROTHY SADAR, YAN LUPING, NASRIN R MAWJI
• Format: Patent
• Language: English; Japanese
• Published: 10.09.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide androgen receptor modulators and methods for their use.SOLUTION: The invention provides compounds having a structure in the figure or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof. In the formula, Y1 and Y2 represent O or S; R1 represents H, alkyl, or the like; R2 represents H, -C(=O)R7, or -S(O)nR8; one of R3 and R4 represents 3,3,3-trichloropropyl; R5 and R6 represent H, OH, alkyl, or the like; and R7 and R8 represent alkyl or the like.SELECTED DRAWING: Figure 1 【課題】アンドロゲン受容体調節物質及びその使用方法を提供する。【解決手段】下記の構造を有する化合物、またはその薬学的に受容可能な塩、互変異性体、もしくは立体異性体。式中、Ｙ１及びＹ２は、ＯまたはＳ、Ｒ１は、Ｈ、アルキル等、Ｒ２は、Ｈ、−Ｃ（＝Ｏ）Ｒ７または−Ｓ（Ｏ）ｎＲ８、Ｒ３またはＲ４の一つは、３，３，３−トリクロロプロピル、Ｒ５及びＲ６は、Ｈ、ＯＨ、アルキル等、Ｒ７及びＲ８は、アルキル等を表す。【選択図】図１