INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1

To provide compositions and methods for treating cancer and neoplastic disease, by inhibiting lysine specific demethylase-1.SOLUTION: A compound having the structure of Formula (IV), or a pharmaceutically acceptable salt thereof, X and Y are each independently chosen from C-H, C-F, C-CH, and N, and...

Full description

Saved in:
Bibliographic Details
Main Authors YOUNG K CHEN, JAMES MARVIN VEAL, JEFFREY ALAN STAFFORD, TOUFIKE KANOUNI
Format Patent
LanguageEnglish
Japanese
Published 20.08.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:To provide compositions and methods for treating cancer and neoplastic disease, by inhibiting lysine specific demethylase-1.SOLUTION: A compound having the structure of Formula (IV), or a pharmaceutically acceptable salt thereof, X and Y are each independently chosen from C-H, C-F, C-CH, and N, and R is aryl, heteroaryl, alkynyl, or cycloalkyl alkenylene.SELECTED DRAWING: None 【課題】リジン特異的なデメチラーゼ−１を阻害することにより癌および腫瘍疾患を処置する組成物及び方法の提供。【解決手段】式（ＩＶ）の構造を有する化合物またはその薬学的に許容可能な塩。(式中、ＸとＹは各々、Ｃ−Ｈ、Ｃ−Ｆ、Ｃ−ＣＨ３、またはＮから独立して選択され、Ｒはアリール、ヘテロアリール、アルキニル、またはシクロアルキルアルキニレンである。）【選択図】なし
Bibliography:Application Number: JP20200072573