BENZOAZEPINE DERIVATIVE

• Main Authors: MATSUDA SATOSHI, MENJO YASUHIRO, HANARI YASUTAKA, TANAKA HIROTAKA, FUJITA SHIGEKAZU, TAKUWA MASAKUNI, URUSHIJIMA TATSUYA, FUJIWARA HIDETO, SUGA KEIZO, OTATSU KAZUHIRO, YAMABE HOKUTO
• Format: Patent
• Language: English; Japanese
• Published: 06.08.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

To provide a novel benzoazepine compound that has vasopressin Vand Vantagonism, and excellent metabolic stability and absorbency, or a salt thereof, and a pharmaceutical use of the compound.SOLUTION: The present invention provides a novel benzoazepine compound represented by formula (1) or a salt thereof [where Ris an optionally substituted Calkyl or the like; L is -C(=O)-NH- or the like; ring Ais a hydrocarbon ring or the like; ring Ais a hydrocarbon ring or the like; ring Aand Amay each have at least one substituent].SELECTED DRAWING: None 【課題】バソプレシンＶ１ａ及びＶ２拮抗作用を有し、良好な代謝安定性及び吸収性を有する新規なベンゾアゼピン化合物又はその塩及び当該化合物の医薬用途を提供する。【解決手段】式（１）で表される新規なベンゾアゼピン化合物又はその塩を提供する。［式中、Ｒ１は、置換されていてもよいＣ１−６アルキル等を示す；Ｌは、−Ｃ（＝Ｏ）−ＮＨ−等を示す；環Ａ１は、炭化水素環等を示す；環Ａ２は、炭化水素環等を示す；環Ａ１及びＡ２はそれぞれ、少なくとも１個の置換基を有していてもよい。］【選択図】なし