OPTIMIZED MONOCLONAL ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR (TFPI)

• Main Authors: PETER SCHOLZ, CHRISTIAN VOTSMEIER, JUNLIANG PAN, SUSANNE STEINIG, WANG ZHUOZHI, JAN TEBBE, JOANNA GRUDZINSKA, JOERG BIRKENFELD, NINA WOBST, SIMONE BRUECKNER
• Format: Patent
• Language: English; Japanese
• Published: 06.08.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide isolated monoclonal antibodies that bind a human tissue factor pathway inhibitor (TFPI).SOLUTION: Isolated monoclonal antibodies that bind a human tissue factor pathway inhibitor include a heavy chain comprising a specific amino acid sequence, the amino acid sequence including one or more amino acid modifications. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.SELECTED DRAWING: None 【課題】ヒト組織因子経路インヒビター（ＴＦＰＩ）に結合する単離されたモノクローナル抗体が提供される。【解決手段】ヒト組織因子経路インヒビターに結合する単離されたモノクローナル抗体であって、特定のアミノ酸配列を含む重鎖を含み、該アミノ酸配列は１つ以上のアミノ酸修飾を含む抗体。ＴＦＰＩに結合するモノクローナル抗体をコードする単離された核酸分子もまた考えられる。抗−ＴＦＰＩモノクローナル抗体を含む医薬組成物および該抗体の投与による凝固における欠乏または欠損を処置する方法もまた提供される。該抗体を生産する方法もまた提供される。【選択図】なし