BIGUANIDE COMPOUND AND USE THEREOF

• Main Authors: KOOK JI AE, HEO HYE JIN, JEONG JAE KAP, LEE JI SUN, KIM HONG WOO, LEE HONG BUM, KIMU SONUKU
• Format: Patent
• Language: English; Japanese
• Published: 30.07.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a novel guanidine derivative or a pharmaceutically acceptable salt thereof which exhibits an excellent effect of suppressing cancer cell proliferation, cancer metastasis and cancer recurrence even at a low dose compared with existing drugs, and to provide a method for preparing the same.SOLUTION: There is provided a guanidine derivative such as N1-phenethyl-N2-(4-bromo)phenyl biguanide, N1-(4-chloro)benzyl-N2-cycloheptyl biguanide, and N1-(benzo[d][1,3]dioxol-5-yl)methyl-N2-ethyl biguanide. It can be effectively used for preventing or treating various cancers such as uterine cancer, breast cancer, gastric cancer, brain cancer, rectal cancer, colon cancer, lung cancer, skin cancer, blood cancer, and liver cancer, and inhibiting cancer cell proliferation and cancer metastasis.SELECTED DRAWING: None 【課題】既存の薬剤と比べて低用量であっても、癌細胞増殖、癌転移及び癌再発を抑制する優れた効果を示す新規のグアニジン誘導体又はその薬学的に許容される塩及びその調製方法を提供する。【解決手段】N1-フェネチルN2-(4-ブロモ)フェニルビグアニド、N1-(4-クロロ)ベンジル-N2-シクロヘプチルビグアニド、N1-(ベンゾ[d][1,3]ジオキソール-5-イル)メチル-N2-エチルビグアニド等のグアニジン誘導体。子宮癌、乳癌、胃癌、脳癌、直腸癌、大腸癌、肺癌、皮膚癌、血液癌、肝臓癌等の種々の癌の予防又は治療や、癌細胞増殖及び癌転移の抑制に効果的に用いることができる。【選択図】なし