COMPUTATIONAL ANALYSIS OF BIOLOGICAL DATA USING MANIFOLD AND HYPERPLANE

• Main Authors: ERAN EDEN, ROY NAVON, BOICO OLGA, ASSAF COHEN-DOTAN, KFIR OVED
• Format: Patent
• Language: English; Japanese
• Published: 27.07.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

To provide a method of analyzing biological data containing expression values of a plurality of polypeptides in blood of a subject.SOLUTION: A method disclosed herein comprises calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction. The method further comprises correlating the distance to the presence of, absence of, or likelihood that the subject has a bacterial infection. The coordinate is defined by a combination of the expression values, where at least 90% of the segment is between a lower bound line and an upper bound line.SELECTED DRAWING: None 【課題】対象の血液中の複数のポリペプチドの発現値を含有する生物学的データを分析する方法を提供する。【解決手段】方法は、曲線のセグメントと、方向によって規定される軸との距離を算出することを含み、その距離は、方向に沿った座標によって規定される曲線上の点で算出される。方法は、距離を、細菌感染の存在、非存在、または対象が細菌感染を有する尤度と相関付けることをさらに含む。座標は、発現値の結合によって規定され、セグメントの少なくとも９０％が下限線と上限線との間にある。【選択図】なし