METHOD FOR PREDICTING BIOKINETICS OF LIQUID PHARMACEUTICAL COMPOSITION

To provide methods for predicting the biokinetics of component 1 obtained when one or more liquid pharmaceutical compositions containing the medicinal component (component 1) are subcutaneously administered to a mammal, and superiority or inferiority thereof.SOLUTION: Provided is a method and the li...

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Bibliographic Details
Main Authors MIYABE KOHEI, KODAMA TOSHIYUKI
Format Patent
LanguageEnglish
Japanese
Published 27.07.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide methods for predicting the biokinetics of component 1 obtained when one or more liquid pharmaceutical compositions containing the medicinal component (component 1) are subcutaneously administered to a mammal, and superiority or inferiority thereof.SOLUTION: Provided is a method and the like for predicting biokinetics parameters of component 1 and/or superiority or inferiority thereof, which is obtained by subcutaneously administering each of the compositions to a mammal, based on the elution result of component 1 obtained by applying one or more liquid compositions containing component 1 to an ion exchange chromatography.SELECTED DRAWING: None 【課題】薬効成分（成分１）を含有する１又は２種以上の液状医薬組成物を哺乳動物に皮下投与した際に得られる成分１の体内動態やその優劣等を予測する方法等。【解決手段】成分１を含有する１又は２種以上の液状組成物をイオン交換クロマトグラフィーに適用して得られる成分１の溶出結果に基づいて、当該各組成物を哺乳動物に皮下投与して得られる成分１の薬物動態学的パラメータおよび／またはその優劣を予測する等。【選択図】なし
Bibliography:Application Number: JP20200068360