SOLUBLE ESTRADIOL CAPSULE FOR VAGINAL INSERTION

To provide an estrogen-based vaginal suppository that provides ease of administration/insertion, improves safety of insertion, eliminates or minimizes vaginal discharge following administration, and does not require vaginal secretions to activate the formulation.SOLUTION: An encapsulated liquid phar...

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Bibliographic Details
Main Authors PETER H R PERSICANER, THORSTEINN THORSTEINSSON, BRIAN A BERNICK, JANICE LOUISE CACACE, JULIA M AMADIO
Format Patent
LanguageEnglish
Japanese
Published 02.07.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide an estrogen-based vaginal suppository that provides ease of administration/insertion, improves safety of insertion, eliminates or minimizes vaginal discharge following administration, and does not require vaginal secretions to activate the formulation.SOLUTION: An encapsulated liquid pharmaceutical formulation for intra-vaginal delivery of estradiol comprises estradiol that is solubilized in one or more C6-C14 fatty acid mono-, di-, or triesters of glycerol or one or more other glycols.SELECTED DRAWING: Figure 2 【課題】投与／挿入が容易であり、挿入による安全性が改善され、投与後の膣からの排出がなく、又は最小限であり、かつ、製剤の活性化に膣分泌物を必要としないエストロゲン系膣坐剤の提供。【解決手段】エストラジオールの膣内送達用カプセル化液体医薬製剤であって、１種以上のグリセロールのＣ６〜Ｃ１４脂肪酸モノ−、ジ−、若しくはトリエステル、又は１種以上の他のグリコール中に可溶化されるエストラジオールを含む、製剤。【選択図】図２
Bibliography:Application Number: JP20200030544