NOVEL MANUFACTURING METHOD OF CHROMANONE DERIVATIVE

• Main Authors: LEE SUNG AH, CHOI KWANG DO, HEO SEUNGPYEONG, KIM EUN SEON, KWEON JAE HONG, LEE JI YUN, KO DONG HYUN, KIM YONGZU
• Format: Patent
• Language: English; Japanese
• Published: 25.06.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

To provide a manufacturing method of a 5,7-difluorochroman-4-on derivative, which does not necessitate a separate purification process and can industrially mass-produce with generally usable reagent and solvent that are low cost and not required to control environment.SOLUTION: A manufacturing method of a compound represented by chemical formula III includes: a first step of manufacturing a compound represented by the following chemical formula VI by reacting a compound represented by the following chemical formula I with acrylonitrile with copper hydroxide as a base; a second step of manufacturing a compound represented by chemical formula II by hydrolyzing the compound represented by the chemical formula VI; and a third step of manufacturing a compound represented by chemical formula III by cyclization reacting a compound represented by the chemical formula II under the presence of an acid.SELECTED DRAWING: None 【課題】別途の精製工程を必要とせず、低コストで、環境規制も受けない一般的に使用可能な試薬と溶媒を用いて産業的に大量生産が可能な、５，７−ジフルオロクロマン−４−オン誘導体の製造方法の提供。【解決手段】下記化学式Ｉで表される化合物を塩基として水酸化銅を用いてアクリロニトリルと反応させ、下記化学式ＶＩで表される化合物を製造する第１のステップ、前記化学式ＶＩで表される化合物を加水分解し、化学式ＩＩで表される化合物を製造する第２のステップ、及び前記化学式ＩＩで表される化合物を酸の存在下で環化反応させ、化学式ＩＩＩで表される化合物を製造する第３のステップを含む、化学式ＩＩＩで表される化合物の製造方法。【選択図】なし