ADRENOMEDULLIN TO GUIDE THERAPY OF BLOOD PRESSURE DECLINE

• Main Author: BERGMANN ANDREAS
• Format: Patent
• Language: English; Japanese
• Published: 14.05.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

To provide an in vitro method for identifying a subject in need of administration of fluid resuscitation or a vasopressor.SOLUTION: An in vitro method includes the steps of: measuring level of proADM and/or fragments thereof having at least 6 amino acids in bodily fluid of the subject; correlating the level with a need in a patient for fluid resuscitation or administration of a vasopressor; and identifying the patient as having such a need if the level of the proADM and/or the fragments thereof having at least the 6 amino acids in the bodily fluid of the patient exceeds a threshold.SELECTED DRAWING: Figure 1 【課題】本発明の課題は、輸液蘇生又は昇圧剤の投与を必要とする対象を同定するためのｉｎ ｖｉｔｒｏ方法を提供することである。【解決手段】当該ｉｎ ｖｉｔｒｏ方法は、対象の体液中のプロＡＤＭ及び／又はその少なくとも６のアミノ酸を有する断片のレベルを測定し、当該レベルを、輸液蘇生又は昇圧剤の投与の患者における必要性と相関させ、ここで当該患者の体液中のプロＡＤＭ及び／又はその少なくとも６アミノ酸を有する断片のレベルが閾値を超えている場合に、当該患者を、そのような必要性があると同定する、工程を含むことによる。【選択図】図１