COMBINED PREPARATIONS FOR TREATING CANCER OR INFECTION

• Main Authors: CHRYSTELLE BRIGNONE, FREDERIC TRIEBEL
• Format: Patent
• Language: English; Japanese
• Published: 14.05.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide combined preparations for treating cancers or infections.SOLUTION: Disclosed herein are a combined preparation and a pharmaceutical composition, both comprise: (a) an LAG-3 protein or derivative thereof that can bind to MHC class II molecule; and (b) a programmed cell death protein-1 (PD-1) pathway inhibitor. PD-1 pathway inhibitors, e.g., anti-PD-1 antibodies or anti-PD-L1 antibodies and soluble derivatives of LAG-3 that act as an APC activator, together synergistically activate T cells (in particular, CD8T cells). Also disclosed are use of the combined preparations and compositions as medicaments, in particular use for treating cancer or infection, as well as a method for treating cancer or infections.SELECTED DRAWING: None 【課題】がんまたは感染を処置するための組合せ調製物の提供。【解決手段】（ａ）ＬＡＧ−３タンパク質、またはＭＨＣクラスＩＩ分子に結合することができるその誘導体；および（ｂ）プログラム細胞死タンパク質−１（ＰＤ−１）経路阻害剤を含む、組合せ調製物および医薬組成物が記載される。ＰＤ−１経路阻害剤、例えば抗ＰＤ−１抗体または抗ＰＤ−Ｌ１抗体、およびＡＰＣ活性化因子として作用するＬＡＧ−３の可溶性誘導体は、Ｔ細胞（特に、ＣＤ８＋Ｔ細胞）を一緒に相乗的に活性化する。組合せ調製物および組成物の医薬としての、特にがんまたは感染の処置のための使用、およびがんまたは感染の処置のための方法が記載される。【選択図】なし