TRIPLE SPECIFICITY BINDING MOLECULE AND USE METHOD THEREOF

• Main Authors: BHASWATI BARAT, JOHNSON LESLIE S, LING HUANG, KALPANA SHAH, STEPHEN JAMES BURKE, GURUNADH REDDY CHICHILI, PAUL A MOORE, LIU LIQIN, CHIA-YING KAO LAM, EZIO BONVINI
• Format: Patent
• Language: English; Japanese
• Published: 14.05.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide a triple specificity binding molecule which is a multiple chain polypeptide molecule comprising three binding domains and capable of mediating coordinate binding to three epitopes.SOLUTION: A triple specificity binding molecule is selected so as to bind to three different epitopes. These epitopes may be epitopes of a same antigen or epitopes of two or three different antigens. In a preferable embodiment, one of these epitopes can bind to a CD3, a second epitope of these epitopes can bind to a CD8, and a third epitope of these epitopes can bind to an epitope of a disease related antigen. There are also provided a novel ROR1 binding antibody and a derivative thereof and a use method of the composition.SELECTED DRAWING: Figure 4A 【課題】３つの結合ドメインを有し、３つのエピトープへの配位結合を仲介できる多重鎖ポリペプチド分子である、三重特異性結合分子を提供する。【解決手段】三重特異性結合分子が、いずれの３つの異なるエピトープに結合できるように選択された結合ドメイン。このようなエピトープは、同一の抗原のエピトープ又は２つ若しくは３つの異なる抗原のエピトープであってよい。好ましい実施形態では、このようなエピトープのうちの１つはＣＤ３に結合でき、このようなエピトープのうちの第２のものはＣＤ８に結合でき、このようなエピトープのうちの第３のものは疾患関連抗原のエピトープに結合できる。新規のＲＯＲ１結合性抗体及びその誘導体、並びにこのような組成物のための使用法。【選択図】図４Ａ