TRIPLE SPECIFICITY BINDING MOLECULE AND USE METHOD THEREOF
To provide a triple specificity binding molecule which is a multiple chain polypeptide molecule comprising three binding domains and capable of mediating coordinate binding to three epitopes.SOLUTION: A triple specificity binding molecule is selected so as to bind to three different epitopes. These...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | English Japanese |
Published |
14.05.2020
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Subjects | |
Online Access | Get full text |
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Summary: | To provide a triple specificity binding molecule which is a multiple chain polypeptide molecule comprising three binding domains and capable of mediating coordinate binding to three epitopes.SOLUTION: A triple specificity binding molecule is selected so as to bind to three different epitopes. These epitopes may be epitopes of a same antigen or epitopes of two or three different antigens. In a preferable embodiment, one of these epitopes can bind to a CD3, a second epitope of these epitopes can bind to a CD8, and a third epitope of these epitopes can bind to an epitope of a disease related antigen. There are also provided a novel ROR1 binding antibody and a derivative thereof and a use method of the composition.SELECTED DRAWING: Figure 4A
【課題】3つの結合ドメインを有し、3つのエピトープへの配位結合を仲介できる多重鎖ポリペプチド分子である、三重特異性結合分子を提供する。【解決手段】三重特異性結合分子が、いずれの3つの異なるエピトープに結合できるように選択された結合ドメイン。このようなエピトープは、同一の抗原のエピトープ又は2つ若しくは3つの異なる抗原のエピトープであってよい。好ましい実施形態では、このようなエピトープのうちの1つはCD3に結合でき、このようなエピトープのうちの第2のものはCD8に結合でき、このようなエピトープのうちの第3のものは疾患関連抗原のエピトープに結合できる。新規のROR1結合性抗体及びその誘導体、並びにこのような組成物のための使用法。【選択図】図4A |
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Bibliography: | Application Number: JP20190192047 |