PREMATURE BIRTH RISK DETERMINATION METHOD, PREMATURE BIRTH RISK DETERMINATION DEVICE

• Main Authors: MIYAUCHI MUTSUMI, MIKAMI TOSHIYUKI, KUDO MIKI, TAKADA TAKASHI, TAKASHIMA YOSHIKI
• Format: Patent
• Language: English; Japanese
• Published: 05.03.2020
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; SPIRITS; TESTING; VINEGAR; WINE

To provide a premature birth risk determination method capable of determining premature birth risk earlier and at lower galectin-3 concentrations than previously reported.SOLUTION: In the premature birth risk determination method, when defining, in blood, plasma or serum, the lower limit of the concentration of galectin-3 as 7 ng/ml and the upper limit as 13 ng/ml, the galectin-3 concentration of blood, plasma, or serum samples collected from a pregnant human woman from gestational age 22 weeks and 0 days to 33 weeks and 6 days is measured; when the galectin-3 concentration falls within a range of caution that is not less than the lower limit and less than the upper limit, it is determined that there is a risk of premature birth.SELECTED DRAWING: Figure 2 【課題】従来報告されていたよりも早い時期に、かつ、さらに低いガレクチン−３濃度で早産リスクの判定を可能とする。【解決手段】血液、血漿又は血清中のガレクチン−３濃度の下限値を７ｎｇ／ｍｌとし、上限値を１３ｎｇ／ｍｌとしたときに、在胎２２週０日から３３週６日までのヒト妊婦から採取された血液、血漿又は血清である検体のガレクチン−３濃度を測定し、該ガレクチン−３濃度が、前記下限値以上かつ前記上限値未満の注意範囲に該当することをもって早産要注意と判定する、早産リスク判定方法。【選択図】図２