METHOD FOR PRODUCING OXIDATION STRESS INHIBITOR, AND OXIDATION STRESS INHIBITOR

• Main Authors: KITAYAMA RYUICHI, NISHITSUJI KAZUCHIKA, FUJII AKIRA, MIZOGUCHI KUNIHIRO, KAMEI YUJI, TSUNEYAMA KOICHI, DOAI HIROYUKI, SAEKI YUKINORI, HATTA HIDEKI, YOSHIDA MASATOSHI
• Format: Patent
• Language: English; Japanese
• Published: 23.01.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a method for preparing a bittern-derived oxidation stress inhibitor, and an oxidation stress inhibitor of a cell.SOLUTION: A method includes: a process of removing precipitate after adding carbonate of alkali metal bittern obtained from deep seawater and preparing bittern-derived Mg-removed liquid; a process of adding alcohol of carbon number 1 to 5 to the bittern-derived Mg-removed liquid to remove precipitate and preparing bittern-derived alcohol-insoluble substance-removed liquid; and a process of sterilizing the bittern-derived alcohol-insoluble substance-removed liquid. Oxidation stress during cell culture is suppressed.SELECTED DRAWING: None 【課題】ニガリ由来の酸化ストレス抑制剤の調製方法および細胞の酸化ストレス抑制剤を提供する。【解決手段】海洋深層水から得たニガリにアルカリ金属の炭酸塩を添加した後沈殿物を除去してニガリ由来Ｍｇ除去液を調製する工程と、前記ニガリ由来Ｍｇ除去液に炭素数１〜５のアルコールを添加して析出物を除去してニガリ由来アルコール不溶性物質除去液を調製する工程と、前記ニガリ由来アルコール不溶性物質除去液を除菌する工程とを含むことを特徴とする。細胞培養時の酸化ストレスが抑制される。【選択図】なし