PROCESSES FOR PREPARATION OF PYRIMIDINYLCYCLOPENTANE COMPOUNDS

To provide processes for preparation of pyrimidinylcyclopentane compounds which are useful as intermediates in preparation of AKT protein kinase inhibitors with therapeutic activity against diseases such as cancer.SOLUTION: The invention provides processes for preparation of the compounds in the fig...

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Bibliographic Details
Main Authors REINHARD REENTS, MICHELANGELO SCALONE, FRANCIS GOSSELIN, HANS IDING
Format Patent
LanguageEnglish
Japanese
Published 26.12.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide processes for preparation of pyrimidinylcyclopentane compounds which are useful as intermediates in preparation of AKT protein kinase inhibitors with therapeutic activity against diseases such as cancer.SOLUTION: The invention provides processes for preparation of the compounds in the figure through amidation coupling reaction.SELECTED DRAWING: None 【課題】癌などの疾患に対する治療活性を有するＡＫＴプロテインキナーゼ阻害薬の調製における中間体として有用であるピリミジニルシクロペンタン化合物の調製方法の提供。【解決手段】アミド化カップリング反応による下記化合物の調製方法。【選択図】なし
Bibliography:Application Number: JP20190155667