EPITOPE OF HEPATITIS B VIRUS SURFACE ANTIGEN AND BINDING MOLECULE SPECIFICALLY BINDING TO SAME FOR NEUTRALIZING HEPATITIS B VIRUS

• Main Authors: KIM CHEOL MIN, LEE HWA JIN, CHANG SHIN JAE, HONG SEUNG SUH, YI KYE SOOK, YOON JOON SUN, LIM BYUNG PIL
• Format: Patent
• Language: English; Japanese
• Published: 19.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide an epitope of hepatitis B virus surface antigen and a binding molecule specifically binding to the same for neutralizing hepatitis B virus.SOLUTION: The present invention relates to an epitope specific to hepatitis B virus surface antigen and a binding molecule binding to the same for neutralizing hepatitis B virus. Since the epitope provided by the present invention is produced by forming a three-dimensional structure and does not comprise an a-determinant, by which escape mutation is induced against an administration of existing vaccines or HBIg, a composition comprising an antibody biding to the epitope or a vaccine composition comprising the epitope has a very low possibility of causing a decrease in efficacy due to escape mutation. Therefore, such an antibody or vaccine composition can be very effectively used in prevention and/or treatment of HBV.SELECTED DRAWING: None 【課題】Ｂ型肝炎ウイルス表面抗原のエピトープおよびこれに特異的に結合するＢ型肝炎ウイルス中和結合分子の提供。【解決手段】本発明は、Ｂ型肝炎ウイルス表面抗原の特異的エピトープとこれに結合するＢ型肝炎ウイルス中和結合分子に関する。本発明が提供するエピトープは、三次元的構造を形成することにより生成され、既存のワクチンまたはＨＢＩｇの投与に対する回避突然変異が生成されるａ決定基を含まないことから、これに結合する抗体を含む組成物または前記エピトープを含むワクチン組成物は、回避突然変異による効能の低下が生じる可能性が非常に低い。したがって、このような抗体またはワクチン組成物は、ＨＢＶの予防および／または治療に非常に有用に使用可能である。【選択図】なし