FEED FOR NON-ALCOHOLIC STEATOHEPATITIS-INDUCED EXPERIMENTAL ANIMAL AND METHOD FOR PRODUCING THE SAME, AND METHOD FOR MAKING NON-ALCOHOLIC STEATOHEPATITIS MODEL ANIMALS

• Main Authors: KAWAGUCHI TAKUYA, TAKANASHI SHINICHIRO, MIKAMI HAYATO, MOMOSE SEIICHI
• Format: Patent
• Language: English; Japanese
• Published: 28.11.2019
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; FODDER; FOODS OR FOODSTUFFS; FORESTRY; HUMAN NECESSITIES; HUNTING; NEW BREEDS OF ANIMALS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; TRAPPING

To provide feed for producing, without using genetic defects or drugs, NASH-induced experimental animals that show a pathological condition closer to that of NASH, the feed being a feed for NASH-induced experimental animal which does not affect the growth of experimental animals, to provide methods for producing the same and to provide methods for making NASH model animals.SOLUTION: Non-alcoholic steatohepatitis-induced experimental animal feed containing 35-60 mass% of carbohydrate source, 10-25 mass% of amino acid source, 15-35 mass% of fats and oils, and 3-8 mass% of minerals and/or metal salts, contains (i) 0.05 to 0.4 mass% of methionine as the amino acid source, (ii) 0.01 mass% or less of cholines, and (iii) 0.05 to 0.5 mass% of an iron compound as the minerals and/or metal salts. There are also provided a method for producing the same and a method for producing non-alcoholic steatohepatitis model animals.SELECTED DRAWING: None 【課題】遺伝子欠損や薬剤を用いることなく、ＮＡＳＨの病態により近い病態を示すＮＡＳＨ誘発実験動物を作出するための飼料であって、且つ実験動物の生育に影響を与えない、ＮＡＳＨ誘発実験動物用飼料およびその製造方法、並びにＮＡＳＨモデル動物の作出方法を提供する。【解決手段】炭水化物源３５〜６０質量％、アミノ酸源１０〜２５質量％、油脂類１５〜３５質量％、並びにミネラル類および／または金属塩類３〜８質量％を含有する非アルコール性脂肪肝炎誘発実験動物用飼料において、（ｉ）前記アミノ酸源として、メチオニン０．０５〜０．４質量％を含有し、（ｉｉ）コリン類の含有量が０．０１質量％以下であり、（ｉｉｉ）前記ミネラル類および／または金属塩類として、鉄化合物０．０５〜０．５質量％を含有する実験動物用飼料およびその製造方法、並びに非アルコール性脂肪肝炎モデル動物の作出方法である。【選択図】なし