2,3-DISUBSTITUTED PYRIDINE COMPOUNDS AS TGF-BETA INHIBITORS AND METHODS OF USE

To provide compounds that inhibit signaling by a member of the TGF-β superfamily to treat cancer.SOLUTION: There are provided 2,3-disubstituted pyridine compounds illustrated below.SELECTED DRAWING: None 【課題】ＴＧＦ−βスーパーファミリーのメンバーによるシグナル伝達を阻害してがんを治療する化合物の提供。【解決手段】下記に例示する２，３−二置換ピリジン化合物。【選択図】なし...

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Main Authors SOMASEKHAR BHAMIDIPATI, TODD KINSELLA, DING PINGYU, MARINA GELMAN, RAJINDER SINGH, DONALD PAYAN
Format Patent
LanguageEnglish
Japanese
Published 14.11.2019
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide compounds that inhibit signaling by a member of the TGF-β superfamily to treat cancer.SOLUTION: There are provided 2,3-disubstituted pyridine compounds illustrated below.SELECTED DRAWING: None 【課題】ＴＧＦ−βスーパーファミリーのメンバーによるシグナル伝達を阻害してがんを治療する化合物の提供。【解決手段】下記に例示する２，３−二置換ピリジン化合物。【選択図】なし
Bibliography:Application Number: JP20190134857