Cot MODULATOR AND APPLICATION METHOD THEREFOR

To provide a Cot modulator and an application method therefor.SOLUTION: The disclosure generally relates to a modulator of Cot (cancer Osaka thyroid), an application method and manufacturing method therefor. The disclosure provides a compound for regulating expression and activity of Cot. The disclo...

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Main Authors KIM MUSONG, WATKINS WILLIAM J, GARY PHILLIPS, JAMES G TAYLOR, CHRISTOPHER T CLARK, THORSTEN A KIRSCHBERG, GAYATRI BALAN, CHOU CHIEN-HUNG, KIRK L STEVENS, JEROMY J COTTELL, SCOTT D SCHROEDER, JOHN O LINK, ELIZABETH M BACON, NEIL H SQUIRES, NATHAN E WRIGHT, SHEILA M ZIPFEL
Format Patent
LanguageEnglish
Japanese
Published 17.10.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a Cot modulator and an application method therefor.SOLUTION: The disclosure generally relates to a modulator of Cot (cancer Osaka thyroid), an application method and manufacturing method therefor. The disclosure provides a compound for regulating expression and activity of Cot. The disclosure also provides a composition including pharmaceutical compositions, a kit containing the compound, and a method of applying (or administering) and manufacturing the compound. The compound provided herein is useful for treating diseases, disorders or conditions mediated by Cot. The disclosure also provides a compound for application in treatments. The disclosure further provides a compound for application in a method for treating diseases, disorders or conditions mediated by Cot. The disclosure further provides applications of the compound in manufacturing pharmaceuticals for treatment of diseases, disorders or conditions mediated (or at least partially mediated) by Cot.SELECTED DRAWING: None 【課題】Ｃｏｔモジュレーター及びその使用方法を提供すること【解決手段】本開示は一般にＣｏｔ（キャンサーオオサカチロイド）のモジュレーター並びにその使用方法及び製造方法に関する。本開示はＣｏｔの発現および活性を調節する化合物を提供する。本開示は薬学的組成物を含めた組成物、化合物を含むキット並びに化合物を使用（または投与）及び作製する方法も又提供する。本明細書に提供されている化合物はＣｏｔによって媒介される疾患、障害、または状態を処置するのに有用である。本開示は又治療における使用の為の化合物を提供する。本開示はＣｏｔによって媒介される疾患、障害又は状態を処置する方法における使用の為の化合物をさらに提供する。更に本開示はＣｏｔによって媒介される（又は少なくとも部分的に媒介される）疾患、障害又は状態の処置の為の医薬の製造における化合物の使用を提供する。【選択図】なし
Bibliography:Application Number: JP20190137759