OILY ADJUVANT

• Main Authors: JULIE LYDIA FITZPATRICK, DUNCAN MWANGI, MICHAEL CHRISTOPHER FONTAINE, KREBS RICHARD LEE, LAUREN WILMES, KAORI MOHR, SARAH A SALMON, DENNIS L FOSS, PAUL JOSEPH DOMINOWSKI, SANGITA MEDIRATTA, GUILLERMO GALLO, JOHN MORGAN HARDHAM, SHARATH K RAI, SANDRA ANN MARIE LIGHTLE, SHAUNAK VORA, DAVID GEORGE EMSLIE SMITH, ANITA DOROTA JAGLARZ, WILLIAM DONACHIE, SUMAN MAHAN
• Format: Patent
• Language: English; Japanese
• Published: 03.10.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide a novel vaccine composition containing adjuvant for preventing foot-and-mouth disease viral infection (FMDV infection) of mammal which is bovine in particular.SOLUTION: An immunogenic composition contains an effective amount of foot-and-mouth disease virus (FMDV) antigen and adjuvant formulation, in which the adjuvant formulation is water-in-oil type emulsion containing oil phase and water phase, polycationic carrier, and immunostimulatory oligonucleotide containing CpG. It is preferable that the foot-and-mouth disease virus antigen is a virus lacking a leader due to genetic modification, and it is preferable to contain antigen derived from a plurality of FMDV serotypes. It is preferable that the polycationic carrier is DEAE dextran.SELECTED DRAWING: None 【課題】哺乳動物、特に、ウシの口蹄疫ウイルス感染（ＦＭＤＶ感染）を防止するための、アジュバント含有新規ワクチン組成物の提供。【解決手段】有効量の口蹄疫ウイルス（ＦＭＤＶ）抗原及びアジュバント製剤を含む免疫原性組成物であって、前記アジュバント製剤が、油相及び水相、ポリカチオン性担体、並びにＣｐＧを含む免疫刺激性オリゴヌクレオチド、を含む油中水型エマルジョンである、前記免疫原性組成物。前記口蹄疫ウイルス抗原は、遺伝子修飾によりリーダーが欠如したウイルスであることが好ましく、複数のＦＭＤＶ血清型に由来する抗原を含むことが好ましい。前記ポリカチオン性担体はＤＥＡＥデキストランであることが好ましい。【選択図】なし