ANTIBODY SPECIFIC FOR CD22 AND METHODS OF USE THEREOF

• Main Authors: DAVID RABUKA, ROBERT GEORGE EDWARD HOLGATE, FRANCIS JOSEPH CARR
• Format: Patent
• Language: English; Japanese
• Published: 12.09.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide antibodies specific for an epitope present on CD22.SOLUTION: The present invention provides an antibody that specifically binds an epitope in CD22, in which the antibody comprises: an immunoglobulin heavy chain comprising a VH region having the amino acid sequence EVQLVESGGGLVKPGGSLXLSCAASGFAFSIYDMSWVRQAPGKGLEWVAYISSGGGTTYYPDTVKGRFTISRDNAKNXLYLQMXSLRAEDTAMYYCARHSGYGSSYGVLFAYWGQGTLVTVSS (where Xis K or R; Xis S or T; and Xis N or S; and an immunoglobulin light chain.SELECTED DRAWING: Figure 2A 【課題】ＣＤ２２上に存在するエピトープに特異的な抗体の提供。【解決手段】ＣＤ２２のエピトープに特異的に結合する抗体であって、アミノ酸配列、ＥＶＱＬＶＥＳＧＧＧＬＶＫＰＧＧＳＬＸ１ＬＳＣＡＡＳＧＦＡＦＳＩＹＤＭＳＷＶＲＱＡＰＧＫＧＬＥＷＶＡＹＩＳＳＧＧＧＴＴＹＹＰＤＴＶＫＧＲＦＴＩＳＲＤＮＡＫＮＸ２ＬＹＬＱＭＸ３ＳＬＲＡＥＤＴＡＭＹＹＣＡＲＨＳＧＹＧＳＳＹＧＶＬＦＡＹＷＧＱＧＴＬＶＴＶＳＳ（Ｘ１は、ＫまたはＲであり、Ｘ２は、ＳまたはＴであり、Ｘ３は、ＮまたはＳである）を有するＶＨ領域を含む免疫グロブリン重鎖と、免疫グロブリン軽鎖とを含む抗体。【選択図】図２Ａ