PRODUCTION METHOD OF FEBUXOSTAT-CONTAINING TABLET

To provide production methods of febuxostat-containing tablets with excellent elution.SOLUTION: Provided is a production method of a tablet containing as an active ingredient 2-(3-cyano 4-isobutyloxy phenyl)-4-methyl-5-thiazole carboxylic acid, the method comprising a fluid layer granulation step us...

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Bibliographic Details
Main Authors SUGAWARA SATOSHI, TOGO TAICHIRO, GOCHOMORI KAZUHIRO
Format Patent
LanguageEnglish
Japanese
Published 29.08.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide production methods of febuxostat-containing tablets with excellent elution.SOLUTION: Provided is a production method of a tablet containing as an active ingredient 2-(3-cyano 4-isobutyloxy phenyl)-4-methyl-5-thiazole carboxylic acid, the method comprising a fluid layer granulation step using C type crystal of 2-(3-cyano 4-isobutyloxy phenyl)-4-methyl-5-thiazole carboxylic acid having an average particle diameter of 1.0 to 30.0 μm. Preferably, the production method uses polyvinyl alcohol as a binder.SELECTED DRAWING: None 【課題】優れた溶出性を備えたフェブキソスタット含有錠剤の製造方法の提供。【解決手段】平均粒径が１．０〜３０．０μｍである２−（３−シアノ−４−イソブチルオキシフェニル）−４−メチル−５−チアゾールカルボン酸のＣ型結晶を用いて流動層造粒する工程を含むことを特徴とする、２−（３−シアノ−４−イソブチルオキシフェニル）−４−メチル−５−チアゾールカルボン酸を有効成分として含む錠剤の製造方法。好ましくは、結合剤としてポリビニルアルコールを用いる、製造方法。【選択図】なし
Bibliography:Application Number: JP20180028734