HEMISULFATE OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID

• Main Authors: EGGER THOMAS, THOMAS AMMANN, VIOLA GROEHN, MOSER RUDOLF
• Format: Patent
• Language: English; Japanese
• Published: 08.08.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide a hemisulfate of 5,10-methylene-(6R)-tetrahydrofolic acid in a substantially crystalline form, pharmaceutical compositions, and methods of using the same in therapy, preferably chemotherapy.SOLUTION: The invention provides a hemisulfate of 5,10-methylene-(6R)-tetrahydrofolic acid. Preferably, the hemisulfate is in a substantially crystalline form, and has a crystalline purity of at least 80%, preferably 90%, preferably 95%, more preferably 97%, most preferably 99% or more.SELECTED DRAWING: None 【課題】実質的に結晶質形態にある、５，１０−メチレン−（６Ｒ）−テトラヒドロ葉酸のヘミ硫酸塩、並びに、医薬組成物およびその治療、好ましくは化学療法における使用法の提供。【解決手段】５，１０−メチレン−（６Ｒ）−テトラヒドロ葉酸のヘミ硫酸塩であり、好ましくは、実質的に結晶質形態にあり、少なくとも８０％、好ましくは９０％、好ましくは９５％、より好ましくは９７％、最も好ましくは９９％またはそれ以上の結晶純度を有する、該ヘミ硫酸塩。【選択図】なし