METHOD FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES

To provide compounds that are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.SOLUTION: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-he...

Full description

Saved in:
Bibliographic Details
Main Authors CRAIG EDWARD DIXON, CHRISTOPHER M LANTHIER, JAN OUDENES, BORIS GORIN, JOHN MICHAEL JANUSZ, ALAN QUIGBO LU, JAMES DENSMORE COPP
Format Patent
LanguageEnglish
Japanese
Published 25.07.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:To provide compounds that are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.SOLUTION: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, {[(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides.SELECTED DRAWING: None 【課題】プロリルヒドロキシラーゼ阻害剤として、又はプロリルヒドロキシラーゼの阻害が望ましい状態の治療に有用である化合物、及びその製造方法の提供。【解決手段】[(3-ヒドロキシピリジン-2-カルボニル)アミノ]-アルカン酸、誘導体、とりわけ5-アリール置換及び5-ヘテロアリール置換の[(3-ヒドロキシピリジン-2-カルボニル]アミノ｝酢酸の調製方法が、開示される。更に[(3-ヒドロキシピリジン-2-カルボニル)-アミノ]酢酸のプロドラッグ、例えば[(3-ヒドロキシピリジン-2-カルボニル]アミノ｝酢酸エステル及び｛[3-ヒドロキシピリジン-2-カルボニル]アミノ｝酢酸アミドの製造方法が、開示される。【選択図】なし
Bibliography:Application Number: JP20190070979