SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

To provide, e.g., novel kinase modifiers.SOLUTION: Diaminopyrimidine compounds having the structures in the figure, where R, R, R, and Rare as defined herein, are used for production of pharmaceuticals for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inh...

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Main Authors JAYASHREE TIKHE, JAN ELSNER, HILGRAF ROBERT, YOON WON HYUNG, DAVID A PAISNER, SATO YOSHITAKA, MERCEDES DELGADO, PAUL ERDMAN, MCCARRICK MEG, SLOSS MARIAN, MEHRAN F MOGHADDAM, LAURIE ANN LEBRUN, MARK A NAGY, BRYDON L BENNETT, STEPHEN NORRIS, WILLIAM J ROMANOW
Format Patent
LanguageEnglish
Japanese
Published 11.07.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract To provide, e.g., novel kinase modifiers.SOLUTION: Diaminopyrimidine compounds having the structures in the figure, where R, R, R, and Rare as defined herein, are used for production of pharmaceuticals for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.SELECTED DRAWING: None 【課題】新規なキナーゼ修飾剤等を提供すること。【解決手段】本発明の一局面は、下記の構造を有するジアミノピリミジン化合物（Ｒ１、Ｒ２、Ｒ３およびＲ４は、本書において定義されているとおりである）の、肝臓線維疾患またはＪＮＫ経路の阻害によって治療可能または予防可能な症状を治療または予防するための医薬品の製造のための使用に関する。【化１】【選択図】なし
AbstractList To provide, e.g., novel kinase modifiers.SOLUTION: Diaminopyrimidine compounds having the structures in the figure, where R, R, R, and Rare as defined herein, are used for production of pharmaceuticals for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.SELECTED DRAWING: None 【課題】新規なキナーゼ修飾剤等を提供すること。【解決手段】本発明の一局面は、下記の構造を有するジアミノピリミジン化合物（Ｒ１、Ｒ２、Ｒ３およびＲ４は、本書において定義されているとおりである）の、肝臓線維疾患またはＪＮＫ経路の阻害によって治療可能または予防可能な症状を治療または予防するための医薬品の製造のための使用に関する。【化１】【選択図】なし
Author PAUL ERDMAN
MEHRAN F MOGHADDAM
SLOSS MARIAN
SATO YOSHITAKA
WILLIAM J ROMANOW
HILGRAF ROBERT
JAN ELSNER
JAYASHREE TIKHE
STEPHEN NORRIS
YOON WON HYUNG
BRYDON L BENNETT
MCCARRICK MEG
DAVID A PAISNER
MERCEDES DELGADO
MARK A NAGY
LAURIE ANN LEBRUN
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– fullname: MCCARRICK MEG
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DocumentTitleAlternate 置換されたジアミノカルボキサミドおよびジアミノカルボニトリルピリミジン、その組成物、ならびに、それを用いた治療方法
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Snippet To provide, e.g., novel kinase modifiers.SOLUTION: Diaminopyrimidine compounds having the structures in the figure, where R, R, R, and Rare as defined herein,...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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