SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

• Main Authors: JAYASHREE TIKHE, JAN ELSNER, HILGRAF ROBERT, YOON WON HYUNG, DAVID A PAISNER, SATO YOSHITAKA, MERCEDES DELGADO, PAUL ERDMAN, MCCARRICK MEG, SLOSS MARIAN, MEHRAN F MOGHADDAM, LAURIE ANN LEBRUN, MARK A NAGY, BRYDON L BENNETT, STEPHEN NORRIS, WILLIAM J ROMANOW
• Format: Patent
• Language: English; Japanese
• Published: 11.07.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide, e.g., novel kinase modifiers.SOLUTION: Diaminopyrimidine compounds having the structures in the figure, where R, R, R, and Rare as defined herein, are used for production of pharmaceuticals for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.SELECTED DRAWING: None 【課題】新規なキナーゼ修飾剤等を提供すること。【解決手段】本発明の一局面は、下記の構造を有するジアミノピリミジン化合物（Ｒ１、Ｒ２、Ｒ３およびＲ４は、本書において定義されているとおりである）の、肝臓線維疾患またはＪＮＫ経路の阻害によって治療可能または予防可能な症状を治療または予防するための医薬品の製造のための使用に関する。【化１】【選択図】なし