COMBINED TREATMENT METHOD OF CANCER

• Main Author: SEKI TAKEHIKO
• Format: Patent
• Language: English; Japanese
• Published: 04.07.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide medicines/cancer treatment methods in combination with a compound having MDM2 inhibitory activity and a compound having FLT3 inhibitory activity.SOLUTION: Provided is a medicine or a combined treatment method in combination with (3'R,4'S,5'R)-N-[(3R,6S)-6-carbamoyl tetrahydro-2H-pyrane-3-yl]-6"-chloro- 4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2"-oxo-1",2"-dihydrodispiro[cyclohexan-1,2'-pyrrolidine-3',3"-indole]-5'-carboxamide or a pharmaceutically acceptable salt thereof, and N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholine-4-yl-ethoxy)imidazo [2,1-b] [1,3] benzothiazole-2-yl]phenyl}urea or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: None 【課題】MDM2阻害活性を有する化合物とFLT3阻害活性を有する化合物とを組み合わせてなる医薬／がんの治療方法を提供すること。【解決手段】（３'Ｒ，４'Ｓ，５'Ｒ）−Ｎ−［（３Ｒ，６Ｓ）−６−カルバモイルテトラヒドロ−２Ｈ−ピラン−３−イル］−６"−クロロ−４'−（２−クロロ−３−フルオロピリジン−４−イル）−４，４−ジメチル−２"−オキソ−１"，２"−ジヒドロジスピロ［シクロヘキサン−１，２'−ピロリジン−３'，３"−インドール］−５'−カルボキサミドもしくはその薬学的に許容される塩とＮ−（５−ｔｅｒｔ−ブチル−イソオキサゾール−３−イル）−Ｎ'−｛４−［７−（２−モルホリン−４−イル−エトキシ）イミダゾ［２，１−ｂ］［１，３］ベンゾチアゾール−２−イル］フェニル｝尿素もしくはその薬学的に許容される塩とを組み合わせてなる医薬または併用治療方法を提供する。【選択図】なし