HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS BTK ACTIVITY INHIBITOR

To provide a compound that is useful for inhibiting Breton-type tyrosine kinase and treating immune disorders such as inflammation mediated by the kinase.SOLUTION: Provided are heteroaryl pyridone and aza-pyridone compounds exemplified by a deacetylated product of the formula below.SELECTED DRAWING:...

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Bibliographic Details
Main Authors WENDY B YOUNG, WEI BINQING, JAMES JOHN CRAWFORD, DANIEL FRED ORTWINE
Format Patent
LanguageEnglish
Japanese
Published 04.07.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a compound that is useful for inhibiting Breton-type tyrosine kinase and treating immune disorders such as inflammation mediated by the kinase.SOLUTION: Provided are heteroaryl pyridone and aza-pyridone compounds exemplified by a deacetylated product of the formula below.SELECTED DRAWING: None 【課題】ブルトン型チロシンキナーゼを阻害し、当該キナーゼによって媒介される炎症などの免疫障害を治療する上で有用な化合物の提供。【解決手段】下式の脱アセチル化品で例示されるヘテロアリールピリドン及びアザ−ピリドン化合物。【選択図】なし
Bibliography:Application Number: JP20190024668