GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISORDER AND DRUG RESPONSE AND DETECTION METHODS AND USES THEREOF

• Main Authors: PLOUGHMAN LYNN MARIE, RANADE KOUSTUBH, KIRCHGESSNER TODD, CARGILL MICHELE, SHAW PETER, TSUCHIHASHI ZENTA, ZERBA KIM E, IAKOUBOVA OLGA, DEVLIN JAMES J
• Format: Patent
• Language: English; Japanese
• Published: 13.06.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

To improve drug design and treatment.SOLUTION: The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.SELECTED DRAWING: Figure 1 【課題】医薬品の設計および治療を改善すること。【解決手段】本発明は、心臓血管障害、特に、心筋梗塞および脳卒中のような急性冠状動脈事象に関連する遺伝子多型、ならびに、スタチンでの心臓血管障害の処置に対する個体の応答に関連する遺伝子多型の発見に基づく。特に、本発明は、多型を含む核酸分子、このような核酸分子によってコードされる改変タンパク質、多型核酸分子およびタンパク質を検出するための試薬、ならびに核酸分子およびタンパク質を用いる方法、ならびにこれらの検出のための試薬の使用方法に関する。【選択図】図１