TABLET FORMULATION COMPRISING PEPTIDE AND DELIVERY AGENT

To provide solid compositions comprising a GLP-1 peptide and a delivery agent, such as SNAC, and uses thereof.SOLUTION: The present inventors surprisingly found that requirements for physical parameters of tablets, such as density, porosity and/or crushing strength, and methods of preparation of the...

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Bibliographic Details
Main Authors BETTY LOMSTEIN PEDERSEN, ERIK SKIBSTED, SAUERBERG PER, SIMON BJERREGAARD, FLEMMING SEIER NIELSEN
Format Patent
LanguageEnglish
Japanese
Published 16.05.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide solid compositions comprising a GLP-1 peptide and a delivery agent, such as SNAC, and uses thereof.SOLUTION: The present inventors surprisingly found that requirements for physical parameters of tablets, such as density, porosity and/or crushing strength, and methods of preparation of the tablets according to the present invention provide tablets with improved bioavailability of peptides, such as acylated peptides.SELECTED DRAWING: None 【課題】本発明は、GLP-1ペプチド、及び送達剤、例えばSNACを含む固形組成物、並びにその使用に関する。【解決手段】本発明者は、驚くべきことに、本発明による錠剤の物理的パラメータの要件、例えば密度、多孔度及び/又は破砕強度、並びに錠剤の調製方法により、ペプチド、例えばアシル化ペプチドの生物学的利用能が改善された錠剤が提供されることを見出した。【選択図】なし
Bibliography:Application Number: JP20190007588