ANTIBODIES TO QUETIAPINE HAPTENS AND USES THEREOF

• Main Authors: YONG GONG, BART M REMMERIE, ERIC HRYHORENKO, RHYS SALTER, THOMAS R DECORY, LINDA COLT, BANUMATHI SANKARAN, THERESA TUBBS, MATTHEW GARRETT DONAHUE
• Format: Patent
• Language: English; Japanese
• Published: 16.05.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

To provide methods for judging levels of an antipsychotic agent, particularly, methods that can be performed in a prescribing clinician's office (where the treatment for an individual patient can be adjusted accordingly in a much more timely manner) and in other medical settings lacking LC or GC/MS or requiring rapid test results.SOLUTION: Disclosed is an antibody which binds to quetiapine usable in a method for detecting quetiapine in a sample, such as a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.SELECTED DRAWING: None 【課題】抗精神病薬のレベルを判定するための他の方法、特に、処方医師の診療所で行うことができ（その結果、個々の患者に対する治療をより迅速に調整することができる）、及びＬＣ若しくはＧＣ／ＭＳ設備を欠いているか又は迅速な試験結果を必要とする他の医療現場において行うことができる方法の提供。【解決手段】競合的イムノアッセイ方法等において、試料中のクエチアピンを検出するために使用することができる、クエチアピンに結合する抗体が開示される。本抗体は、単一の側方流動アッセイ装置におけるアリピプラゾール、オランザピン、クエチアピン、及びリスペリドンの多重検出を含む、クエチアピンのポイントオブケア検出のために、側方流動アッセイ装置において使用することができる。【選択図】なし