c-Met MODULATOR AND ITS USE

• Main Authors: CHAN DIVA SZE-MING, TAKEUCHI CRAIG STACY, MANN LARRY W, KHOURY RICHARD GEORGE, PARKS JASON JEVIOUS, BANNEN LYNNE CANNE, WANG YONG, DALRYMPLE LISA ESTHER, JAMMALAMADAKA VASU, FORSYTH TIMOTHY PATRICK, MANN GRACE, NUSS JOHN M, ZHU WEI, LEAHY JAMES WILLIAM, CHEN JEFF, MAC MORRISON B, HUYNH TAI PHAT
• Format: Patent
• Language: English; Japanese
• Published: 09.05.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

To provide a compound for modulating protein kinase enzymatic activity.SOLUTION: Provided is a compound for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, provided are quinazoline and quinoline inhibiting, regulating and/or modulating the signal transduction passage of a kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4 related to the changes in cellular activities as mentioned above, a composition containing these compound and a method for using them for treating kinase dependent diseases and conditions. Also provided is a method for producing the above compound, and a method for producing the composition containing these compound.SELECTED DRAWING: None 【課題】プロテインキナーゼ酵素活性を調節するための化合物を提供すること。【解決手段】本発明は、増殖、分化、細胞自己死、遊走および化学浸潤のような細胞活動を調節するためのプロテインキナーゼ酵素活性を調節するための化合物を提供する。より具体的には、本発明は、上記のような細胞活動における変化に関連した、キナーゼレセプター、特に、ｃ−Ｍｅｔ、ＫＤＲ、ｃ−Ｋｉｔ、ｆｌｔ−３およびｆｌｔ−４のシグナル伝達経路を阻害、調整および／または調節する、キナゾリンおよびキノリン、これらの化合物を含む組成物、ならびにキナーゼ依存性疾患および状態を処置するためにそれらを使用する方法を提供する。本発明はまた、上記の化合物を作製するための方法、およびこれらの化合物を含む組成物を作製するための方法を提供する。【選択図】なし