TOLEROGENIC SYNTHETIC NANOCARRIERS AND THERAPEUTIC MACROMOLECULES FOR REDUCED OR ENHANCED PHARMACODYNAMIC EFFECTS

• Main Authors: ROBERTO A MALDONADO, TAKASHI KEI KISHIMOTO
• Format: Patent
• Language: English; Japanese
• Published: 09.05.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide compositions and methods that provide pharmacodynamic effects specific to therapeutic macromolecules.SOLUTION: A method comprising: providing an immunosuppressant dose, wherein the immunosuppressant dose is attached to synthetic nanocarriers; and administering a reduced pharmacodynamically effective dose of a therapeutic macromolecule concomitantly with the immunosuppressant dose to a subject in which an anti-therapeutic macromolecule antibody response is expected to occur; wherein the concomitant administration is according to a protocol that has been demonstrated to result in a pharmacodynamic effect with the reduced pharmacodynamically effective dose of the therapeutic macromolecule upon concomitant administration with the immunosuppressant dose, as compared to administration of the therapeutic macromolecule when not administered concomitantly with the immunosuppressant dose and in the presence of an anti-therapeutic macromolecule antibody response.SELECTED DRAWING: None 【課題】治療用高分子に特異的な薬力学的効果を提供する組成物および方法の提供。【解決手段】免疫抑制剤用量を提供すること、ここで免疫抑制剤用量が合成ナノ担体に付着されている；および、治療用高分子の低減された薬力学的有効用量を、抗治療用高分子抗体応答が起こると予期される対象へ、免疫抑制剤用量と併用投与することを含む方法であって、併用投与が、免疫抑制剤用量と併用投与されず、かつ抗治療用高分子抗体応答の存在下であるときの治療用高分子の投与と比較して、免疫抑制剤用量との併用投与の際に、治療用高分子の低減された薬力学的有効用量により薬力学的効果をもたらすことが実証されたプロトコルに従う、前記方法。【選択図】なし