1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES

• Main Authors: ANDREA ROTGERI, NICO BRAEUER, IOANA NEAGOE, JENS NAGEL, ADAM JAMES DAVENPORT, ANNE-MARIE GODINHO-COELHO, OLIVER MARTIN FISCHER, ANTJE ROTTMANN
• Format: Patent
• Language: English; Japanese
• Published: 18.04.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide novel inhibitors of the P2X3 receptor.SOLUTION: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising the compounds, and to the use of the compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.SELECTED DRAWING: None 【課題】P2X3受容体の新規阻害剤を提供すること。【解決手段】本明細書で記載および定義される一般式（I）の1,3−チアゾール−2−イル置換ベンズアミド化合物、前記化合物を含む医薬組成物および組み合わせ、ならびに唯一の薬剤としてまたは他の有効成分と組み合わせて疾患、特に神経性障害を治療または予防するための医薬組成物を製造するための前記化合物の使用により、上記課題を解決する。【選択図】なし